What is used to create a seal and secure window glass during replacement in a vehicle?

The best choice for securing window glass during replacement in a vehicle is the filler strip. A filler strip is a critical component used in the installation process which is designed to fit into the gap between the glass and the vehicle frame. This strip aids in creating a tight seal, preventing water and air from entering the vehicle, and also helps to provide a finished look to the installation.

Furthermore, a filler strip can help support the glass and ensure that it is properly held in place during and after installation. While resin, molding, and gaskets serve specific purposes in various contexts, the filler strip is specifically tasked with securing the window glass in the vehicle's frame, making it the most appropriate answer to this question.